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KMID : 0385020020180030143
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Korean Journal of Laboratory Animal Science
2002 Volume.18 No. 3 p.143 ~ p.146
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Inflammatory Large Bowel Disease due to Helicobacter hepaticus infection in BALB/cA-Hfh11^n^u Mice
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Kim, Bang Hyun
Won, Young Suk/Lee, Chul Ho/Hyun, Byung Hwa/Kim, Dae-Yong/Choi, Yang Kyu
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Abstract
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The slowly growing microaerophilic Helicobacter sp were isolated from the fecal pallets of 2 BALB/cA-Hfhll^nu mice with rectal prolapse. The rectrums of mice protruded approximately 2 to 3 mm from the anus and varied in color from pale pink to deep red. Histopathologically, chronic proliferative colitis and proctitis were observed. The epithelium were hyperplastic and lymphocyted infiltrated markedly in mucosa and submucosa. Our isolates were characterized by morphological, physiological, molecular methods, special staining, and were confirmed to be H. hepaticus. Spontaneous H. hepaticus-associated inflammatory large bowel disease, to the best of our knowledge, did not previously reported in Korea.
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